EVpedia: a community web portal for extracellular vesicles research

نویسندگان

  • Dae-Kyum Kim
  • Jaewook Lee
  • Sae Rom Kim
  • Dong-Sic Choi
  • Yae Jin Yoon
  • Ji Hyun Kim
  • Gyeongyun Go
  • Dinh Nhung
  • Kahye Hong
  • Su Chul Jang
  • Si-Hyun Kim
  • Kyong-Su Park
  • Oh Youn Kim
  • Hyun Taek Park
  • Ji Hye Seo
  • Elena Aikawa
  • Monika Baj-Krzyworzeka
  • Bas W. M. van Balkom
  • Mattias Belting
  • Lionel Blanc
  • Vincent Bond
  • Antonella Bongiovanni
  • Francesc E. Borràs
  • Luc Buée
  • Edit I. Buzás
  • Lesley Cheng
  • Aled Clayton
  • Emanuele Cocucci
  • Charles S. Dela Cruz
  • Dominic M. Desiderio
  • Dolores Di Vizio
  • Karin Ekström
  • Juan M. Falcon-Perez
  • Chris Gardiner
  • Bernd Giebel
  • David W. Greening
  • Julia Christina Gross
  • Dwijendra Gupta
  • An Hendrix
  • Andrew F. Hill
  • Michelle M. Hill
  • Esther Nolte-'t Hoen
  • Do Won Hwang
  • Jameel Inal
  • Medicharla V. Jagannadham
  • Muthuvel Jayachandran
  • Young-Koo Jee
  • Malene Jørgensen
  • Kwang Pyo Kim
  • Yoon-Keun Kim
  • Thomas Kislinger
  • Cecilia Lässer
  • Dong Soo Lee
  • Hakmo Lee
  • Johannes van Leeuwen
  • Thomas Lener
  • Ming-Lin Liu
  • Jan Lötvall
  • Antonio Marcilla
  • Suresh Mathivanan
  • Andreas Möller
  • Jess Morhayim
  • François Mullier
  • Irina Nazarenko
  • Rienk Nieuwland
  • Diana N. Nunes
  • Ken Pang
  • Jaesung Park
  • Tushar Patel
  • Gabriella Pocsfalvi
  • Hernando del Portillo
  • Ulrich Putz
  • Marcel I. Ramirez
  • Marcio L. Rodrigues
  • Tae-Young Roh
  • Felix Royo
  • Susmita Sahoo
  • Raymond Schiffelers
  • Shivani Sharma
  • Pia Siljander
  • Richard J. Simpson
  • Carolina Soekmadji
  • Philip Stahl
  • Allan Stensballe
  • Ewa Stepien
  • Hidetoshi Tahara
  • Arne Trummer
  • Hadi Valadi
  • Laura J. Vella
  • Sun Nyunt Wai
  • Kenneth W. Witwer
  • María Yáñez-Mó
  • Hyewon Youn
  • Reinhard Zeidler
  • Yong Song Gho
چکیده

MOTIVATION Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. RESULTS We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more than 65 000 times from more than 750 cities. In addition, about 350 members from 73 international research groups have participated in developing EVpedia. This free web-based database might serve as a useful resource to stimulate the emerging field of EV research. AVAILABILITY AND IMPLEMENTATION The web site was implemented in PHP, Java, MySQL and Apache, and is freely available at http://evpedia.info.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles

Secretion of extracellular vesicles is a general cellular activity that spans the range from simple unicellular organisms (e.g. archaea; Gram-positive and Gram-negative bacteria) to complex multicellular ones, suggesting that this extracellular vesicle-mediated communication is evolutionarily conserved. Extracellular vesicles are spherical bilayered proteolipids with a mean diameter of 20-1,000...

متن کامل

Application of extracellular vesicles in the treatment of inflammatory bowel disease

Introduction: Inflammatory bowel disease(IBD) is caused by genetic, environmental, microbial and immune factors. IBD has two primary forms: Ulcerative colitis and Crohn´s disease. The incidence of IBD has significantly increased over the last few decades. Given that patients have poor response to drug treatments or are resistant to drug therapies, new therapies are needed for gastrointestinal i...

متن کامل

Extracellular Vesicles in Regenerative Medicine, a Brief Review

Extracellular vesicles were initially known as cellular waste carriers, while recent studies demonstrate that extracellular vesicles play important biological roles in all aspects of life-from single cells to mammalians. Their pathophysiological roles in some diseases like cancer are being decoded. Extracellular vesicles are divided into some classes and there are different strategies to isolat...

متن کامل

Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies

Extracellular vesicles, naturally released from all cell types including bacteria, are of great importance in medical microbiology due to transporting a variety of biomaterials, enzymes, and virulence factors, regulating immunity, and having roles in colonization and initiation of signaling pathways. These vesicles are also secreted from microbiota in the gastrointestinal tract and affect the h...

متن کامل

EXTRACELLULAR VESICLES AND THEIR THERAPEUTIC APPLICATIONS: A REVIEW

Background & Aims: Extracellular vesicles are double phospholipid layer vesicles releasing from several cells.  These particles contain bio-molecules including mRNA, miRNA, DNA, proteins, and lipids which play a pivotal role in the cell to cell communication. Once delivered, they participate to change target cell function, fate, morphology, differentiation, and growth. The present study is a re...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Bioinformatics

دوره 31 6  شماره 

صفحات  -

تاریخ انتشار 2015